Ethidin

Ranitidine
Antiulcerant

Ethidin

Description

Composition:

Ethidin150 Tablet: Each film coated tablet contains Ranitidine Hydrochloride USP equivalent to Ranitidine 150 mg.

Pharmacology:

Ranitidine is a histamine H2-receptor antagonist. It inhibits gastric acid secretion. H2 -antagonists are rapidly well absorbed after oral administration; peak concentrations in plasma are attained within 1 or 2 hours.
The half-life for elimination of ranitidine is 2 to 3 hours. These drugs are in large part excreted in the urine.

Indications:

  • Treatment of active duodenal ulcer
    • Benign gastric ulcer
    • Treatment & prevention of ulcer associated with non-steroidal
    anti-inflammatory agent
    • Post-operative stress ulcer.
    •Zollinger-Ellison Syndrome.
    •Gastroesophageal reflux disease (GERD).
    •Gastro-intestinal hemorrhage from stress ulcer in seriously ill patient.
    •Recurrent hemorrhage in patients with bleeding peptic ulcer.
    •Before general anesthesia in patient considered to be at risk of acid aspiration particulary obstetric patients.

Dosage & Administration:

Adult: The usual dose of Ranitidine is 150 mg twice daily (in the morning & at bed time) for atleast 4 weeks in the management of duodenal & gastric ulcer. Maintenance dose of 150 mg daily may be given at bed time. In reflux oesophagitis the recommended dose is 150 mg twice daily or 300 mg at bed time for up to 8 weeks. In pathological hypersecretory conditions, such as Zollinger-Ellison Syndrome initial dose is usually 150 mg twice or thrice daily & may be increased upto 6 g daily.

Contraindication:

Patients hypersensitive to Ranitidine.

Warning & Precaution:

Since Ethidin is excreted primarily by the kidney, dosage should be adjusted in patients with impaired renal function. Caution should be taken in patients with hepatic dysfunction. Symptomatic response to Ranitidine therapy does not preclude the presence of gastric malignancy.

Side Effects:

Rarely dizziness, insomnia, reversible mental confusion, diarrhoea, nausea, vomiting, abdominal discomfort.

Pregnancy and Lactation:

Ranitidine crosses the placenta. But there is no evidence of impaired fertility or harm to the fetus due to the Ranitidine. Like other drugs, Ranitidine tablet should only be used during pregnancy if considered essential.
Ranitidine is excreted in human breast milk, Caution should be exercised when the drug is administered to a nursing mother.

Drug interaction:

Increased or decreased prothrombin times have been reported during concurrent use of Ethidin and warfarin. Absorption of ketoconazole is decreased when used with Ranitidine.

Storage:

Store in a cool and dry place, away from light.

Packing:

Ethidin 150 Tablet:Each box contains 100’s tablets.