CASYN ® – Aceclofenac BP

Chemical Name: 2-[2-[2-(2,6-dichloroanilino)phenyl]acetyl]oxyacetic acid

Description: Aceclofenac is indicated for the relief of pain and inflammation in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. Aceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties.

Aceclofenac potently inhibits the cyclo-oxygenase enzyme (COX) that is involved in the synthesis of prostaglandins, which are inflammatory mediators that cause pain, swelling, inflammation, and fever. It is reported to have a higher anti-inflammatory action or at least comparable effects than conventional NSAIDs.

— 100 mg 10×10 Tablets

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CASYN ® – Aceclofenac BP

COMPOSITION
100 mg Tablet: Each film-coated tablet contains Aceclofenac BP 100 mg.

PHARMACOLOGY
Casyn® is a non-steroidal, anti-inflammatory agent with analgesic properties. Its mode of action is largely based on inhibition of prostaglandin synthesis. It is a potent inhibitor of the enzyme cyclooxygenase, which is involved in the production of prostaglandins. It also stimulates cartilage matrix (glycosaminoglycans) synthesis.

INDICATION
Aceclofenac is used to relieve pain, swelling and inflammation of joints in patients suffering from osteoarthritis, rheumatoid arthritis and ankylosing spondylitis (a type of arthritis that causes pain and stiffness in the spine).
It can also be used for short term treatment of pain due to post-operative and post-traumatic cases.

DOSAGE AND ADMINISTRATION
Adults: The maximum recommended dose is 200 mg daily, taken as two separate 100 mg doses, one tablet in the morning and one in the evening.
Children: There is no clinical data on the use of aceclofenac in children.
Elderly: The pharmacokinetics of aceclofenac is not altered in elderly patients. Therefore, it is not considered necessary to modify the dose and dose frequency.

SIDE EFFECT
Generally, aceclofenac is well tolerated.
The majority of side effects observed are gastro-intestinal disturbance, dizziness, vertigo, somnolence, insomnia, pruritus, rash, dermatitis, etc.

PRECAUTION
Aceclofenac should be administered with caution to patients with symptoms indicative of gastro­ intestinal disorders, with a history of peptic ulceration, ulcerative colitis, Crohn’s disease, hepatic porphyria, and coagulation disorders.
Patients suffering from severe hepatic impairment must be monitored.

CONTRAINDICATION
Aceclofenac is contraindicated in patients previously sensitive to aceclofenac or aspirin or other NSAIDs. It should not be administered to patients with active or suspected peptic ulcer or gastro­ intestinal bleeding and moderate to severe renal impairment.

DRUG INTERACTION
Lithium and Digoxin: Aceclofenac, like other NSAIDs, may increase plasma concentra­ tions of lithium and digoxin.
Diuretics: Aceclofenac, like other NSAIDs, may inhibit the activity of diuretics.
Anticoagulants: Like other NSAIDs, Aceclofenac may enhance the activity of anticoagulants.
Quinolones: Convulsion may occur due to an interac­ tion between quinolones and NSAIDs.
Other NSAIDs and steroids: Concomitant therapy with aspirin, other NSAIDs and steroids may increase the frequency of side effects.

USE IN PREGNANCY AND LACTATION
The use of Aceclofenac should be avoided in pregnancy and lactation unless the potential benefits to the mother outweigh the possible risks to the fetus/newborn. This type of drug is not recommended during the last trimester of pregnancy.

STORAGE
Store tablet at or below 30°C. Protect from light & moisture. Keep out of the reach of children.

PACKAGING
CASYN®: Tablet 100 mg: Each box contains 10 strips of 10 tablets in blister pack.

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