Cetirizine Dihydrochloride


Cetirizine dihydrochloride  is a second-generation antihistamine used in the treatment of hay fever, allergies, angioedema, and urticaria. It is a major metabolite of hydroxyzine, and a racemic selective H1 receptor antagonist. Second-generation antihistamines like cetirizine are less able to cross the blood–brain barrier and therefore have diminished effects on the central nervous system compared to first-generation drugs.



Alargol Tablet: Each film coated tablet contains Cetirizine Dihydrochloride INN 10 mg.
AlargolSyrup: Each 5 ml of syrup contains Cetirizine Dihydrochloride INN 5 mg. 



Cetirizine, a piperazine derivative and carboxylated metabolite of hydroxyzine, is a potent antihistamine with distinguishing features like: (1) Exquisite anti-H1 specificity: Cetirizine appears unique in being devoid of action on receptors other than the H1-receptor, (2) Potency: at unit dose Cetirizine is the most potent antihistamine in the skin and lungs & (3) Absence of metabolism. Therefore, Cetirizine is the choice of H1 antagonist for the management of the immediate allergic reactions.
Cetirizine, a new second generation H1-antagonist, is the only antihistamine that possesses activity against both the histamine mediated ‘early’ phase of the allergic reaction and the ‘late’ phase response of immediate hypersensitivity characterize by migration of inflammatory cells to the site of the reaction. It is an effective and well tolerated treatment of seasonal and perennial allergic rhinitis and chronic idiopathic urticaria. 



Cetirizine is indicated for the symptomatic treatment of allergic rhinitis and urticaria.


Dosage & Administration:

Alargol Tablet:
Adults and children over 6 years: 1 tablet once daily or 1/2 tablet twice daily.
Children 2-6 years: 1/2 tablet once daily.
Adults and children over 6 years: 2 teaspoon once daily or 1 teaspoon twice daily.
Children 2-6 years: 1 teaspoonful once daily or 1/2 teaspoon twice daily.



Alargol is contraindicated in patients who have shown hypersensitivity or idiosyncrasy to it or to its parent compound, Hydroxyzine.


Warning & Precaution:

Patients are advised not to exceed the recommended dose if driving car or operating machinery. Caution should be taken with concomitant use of sedatives and some dose reduction may be required if renal function is impaired.


Side Effects:

Alargol is well tolerated and associated with fewer adverse effects compared with first generation antihistamines. Side effects include headache, dry mouth, dizziness, agitation and gastrointestinal upset. Alargol does not produce anticholinergic effects.


Pregnancy and Lactation:

Use in pregnancy : There is inadequate information about its safety during pregnancy. It should be used only if the potential benefit justifies the potential risk to the fetus.
Use in lactation : Nursing mothers are advised not to take this medicine.



Alargol Tablet : Each box contains 100’s tablets in blister pack.
AlargolSyrup : Each bottle contains 60 ml of Alargol liquid.