NEBS PLUS® – Paracetamol + Caffeine

Chemical Name: N-acetyl-para-aminophenol (APAP) / Acetaminophen 1,3,7-Trimethylpurine-2,6-dione

Description: NEBS PLUS® is an analgesic (pain killer) and an antipyretic (helps to reduce body temperature). Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class. Caffeine acts by blocking binding of adenosine to the adenosine A1 receptor, which enhances release of the neurotransmitter acetylcholine. Caffeine also increases cyclic AMP levels through nonselective inhibition of phosphodiesterase. Caffeine is a stimulant present in tea, coffee, cola beverages, analgesic drugs, and agents used to increase alertness. The combination of Paracetamol & Caffeine is used to reduce fever, relief of headache, migraine, neuralgia and rheumatic aches and pains.

— 3×2 Ampoules

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NEBS PLUS® – Paracetamol + Caffeine

COMPOSITION
Tablet: Each film coated tablet contains Paracetamol BP 500mg & Caffeine 65mg

PHARMACOLOGY
This is a combination of Paracetamol and Caffeine. Paracetamol has analgesic and antipyretic properties with weak anti-inflammatory activity. Caffeine is an alkaloid which is a theophylline-like xanthine derivative. By intermolecular association with Paracetamol, Caffeine increases the solubility and transmembrane permeation of Paracetamol. In addition, Caffeine increases the pain threshold and tolerance of pain. Caffeine has also an intrinsic power to raise vessel tone in the brain, which provides another benefit to treat migraine and headache.

INDICATION
Fever, Headache, Migraine, Toothache, Neuralgia, Feverishness, Period pain, Sore throat, Backache, Help to reduce
the temperature, Aches and pain of colds and flu.

DOSAGE AND ADMINISTRATION
Adult dose: 1-2 tablets every 4-6 hours. Maximum dose: 8 tablets daily.
Child dose: Not recommended for children below 12 years

SIDE EFFECT
Side effects of paracetamol are usually mild, though haematological reactions including thrombocytopenia, leukopenia, pancytopenia, neutropenia, and agranulocytosis have been reported. Pancreatitis, skin rashes, and other allergic reactions occur occasionally.

PRECAUTION
Paracetamol & Caffeine should be given cautiously in the following cases: In patients with hepatic or renal failure, in patients taking other hepatotoxic medication. Prolonged use of the drug without consulting a physician should be avoided.

CONTRAINDICATION
Paracetamol is contraindicated in patients with severe renal function impairment and hepatic disease (Viral Hepatitis). Known hypersensitivity to paracetamol or caffeine.

DRUG INTERACTION
May reduce serum levels with anticonvulsants (e.g. phenytoin, barbiturates, carbamazepine). May enhance the anticoagulant effect of warfarin and other coumarins with prolonged use. Accelerated absorption with
metoclopramide and domperidone. May increase serum levels with probenecid. May increase serum levels of chloramphenicol. May reduce absorption with colestyramine within 1 hr of admin. May cause severe hypothermia with phenothiazine.

USE IN PREGNANCY AND LACTATION
Pregnant mothers should consult with doctors before taking Paracetamol & Caffeine. Paracetamol & Caffeine can be taken whilst breast feeding.

STORAGE
Store tablet and powder for suspension at or below 30°C. Protect from light & moisture. Keep out of the reach of children.

PACKAGING
NEBS PLUS® TABLET: Each box contains /100 tablets in blister pack.

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