Clobetasol Propionate
Topical Preparations




Probet Cream: Each gram cream contains Clobetasol Propionate BP 0.5 mg (0.05% w/w).



Clobetasol Propionate is a highly active corticosteroid with topical anti-inflammatory activity. The major effect of Clobetasol Propionate on skin is a non-specific anti-inflammatory response, partially due to vasoconstriction and decrease in collagen synthesis.



  • Eczema unresponsive to weak steroid cream or ointment• Other inflammatory skin disorders resistant to treatment with weaker steroid creams or ointment• Psoriasis.


Dosage & Administration:

Probet Cream
Adults and children over 1 year:
• Apply sparingly to cover the affected area, and gently rub into the skin. Frequency of application is 2 to 3 times daily according to the severity of the condition. The total dose applied should not exceed 50 g weekly.
• Treatment should not be continued for more than 7 days without medical supervision. If a longer course is necessary, it is recommended that treatment should not be continued for more than 4 weeks without the patient’s condition being reviewed.
• Repeated short courses of Clobetasol may be used to control exacerbations

Children below 1 year: Under 1 year this preparation is not recommended


It is contraindicated in rosacea, acne vulgaris, perioral dermatitis, primary cutaneous viral infections (eg. herpes simplex, chickenpox), otitis externa with a perforated eardrum, hypersensitivity to the preparations.


Warning & Precaution:

Long-term continuous topical therapy should be avoided where possible, particularly in infants and children, as adrenal suppression can occur readily even without occlusion. If used in childhood, or on the face, courses should be limited to 5 days and occlusion should not be used. If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye. If used in psoriasis careful patient supervision is important.


Side Effects:

Generally this preparation is well tolerated. However, few side effects after prolonged and intensive treatment may cause local atrophic changes in the skin such as thinning, striae, and dilatation of the superficial blood vessels, particularly when occlusive dressings are used, or when skin folds are involved.


Pregnancy and Lactation:

Pregnancy category C: The safe use of this preparation during pregnancy & lactation has not been established.


Drug interaction:

No hazardous interactions have been reported with use of Clobetasol Propionate.



Probet Cream: Each tube contains 10 gm cream.