Trixim 200 Capsule: Each capsule contains Cefixime Trihydrate BP equivalent to Cefixime 200 mg.

Trlxim 400 Capsule: Each capsule contains CefiximeTrihydrate BP equivalent to Cefixime 400 mg.

Trixim Powder for Suspension: After reconstitution, each 5 ml suspension contains Cefixime Trihydrate BP equivalent to Cefixime 100 mg.


Cefixime is a semi-synthetic, broad spectrum cephalosporin antibiotic of third generation for oral administration. It is a bactericidal antibiotic, kills bacteria by interfering in the synthesis of the bacterial cell wall. Cefixime is highly stable in the presence of beta-lactamase enzymes. Cefixime has marked in-vitro bactericidal activity against a wide variety of Gram-positive and Gram-negative organisms including beta lactamase producers. Clinical efficacy of Cefixime has been demonstrated in infections caused by commonly occurring pathogens including Gram-positive organism Streptococcus pneumoniae, Streptococcus pyogenes, Gram-negative organism Escherichia coli, Proteus mirabilis, Klebsiella spp., Haemophilus influenzae (beta-lactamase positive and negative), Moraxella catarrhalis (beta-lactamase positive and negative), Salmonella typhi and Enterobacter species.


Trixim is indicated in the following infectious diseases-Respiratory Tract Infections: Pneumonia, Sinusitis, Pharyngitis and Tonsillitis, Acute Bronchitis and Acute Exacerbations of Chronic

Bronchitis (AECB),

Otitis Media, Typhoid,

Urinary Tract Infections,

Uncomplicated gonorrhea (cervical/urethral)


Dosage and Administration:

Trixim Capsule :

Adult and child over 12 years: 200 or 400 mg daily as a single dose or in two divided doses.

Trixim Suspension :

Child over 6 months: 8mg/kg daily as a single or in 2 divided doses. The usual treatment of Trixim is 7 days. This may be continued for up to 14 days according to the severity of infection.


Side effects:

Cefixime is generally well tolerated. The majority of adverse reactions observed in clinical trials are mild and self limiting in nature. Gastro-intestinal disturbance: Diarrhea (if severe diarrhea occurs, Cefixime should be discontinued), changes in the color of stool, nausea, abdominal pain, dyspepsia, vomiting, flatulence have been reported. CNS disturbances : Headache, dizziness.

Others : Hypersensitivity reactions which usually subsided upon discontinuation of therapy; infrequent and reversible hematological changes; elevation of serum amylase. 


Cefixime should be prescribed with caution in individuals with a history of gastrointestinal diseases, particularly colitis. Dosage adjustment is only necessary in severe renal failure (creatinine clearance < 20 ml/min)

Contraindications :

Patients with known hypersensitivity to Cefixime or cephalosporin group of drugs.

Use in Pregnancy & Lactation:

Pregnancy: Pregnancy category B. There are no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

Lactation: It is not known whether Cefixime is excreted in human milk. Consideration should be given to discontinuing nursing temporarily during treatment with this drug. 

Drug Interactions:

Carbamazepine: Elevated carbamazepine levels have been reported in postmarketing experience when Cefixime is administered concomitantly. Drug monitoring may be of assistance in detecting alterations in carbamazepine plasma concentrations.

Warfarin and Anticoagulants:

Increased prothrombin time, with or without clinical bleeding, has been reported when cefixime is administered concomitantly. 


Gastric lavage may be indicated; otherwise, no specific antidote exists. Cefixime is not removed in significant quantities from the circulation by hemodialysis or peritoneal dialysis. Adverse reactions in small numbers of healthy adult volunteers receiving single doses up to 2 g of Cefixime did not differ from the profile seen in patients treated at the recommended doses.

Commercial Packaging:

Trixim 200 Capsule: Box containing 12’s Capsule in Alu-Alu blister.

Trixim 400 Capsule:  Box containing 6’s Capsule in  Alu-Alu blister.

Trixim Powder for Suspension:  Bottle containing powder for the preparation of 50 ml suspension.